Super-taxon in human microbiome are identified to be associated with colorectal cancer.

ABSTRACT:

Background

Microbial communities in the human body, also known as human microbiota, impact human health, such as colorectal cancer (CRC). However, the different roles that microbial communities play in healthy and disease hosts remain largely unknown. The microbial communities are typically recorded through the taxa counts of operational taxonomic units (OTUs). The sparsity and high correlations among OTUs pose major challenges for understanding the microbiota-disease relation. Furthermore, the taxa data are structured in the sense that OTUs are related evolutionarily by a hierarchical structure.

Results

In this study, we borrow the idea of super-variant from statistical genetics, and propose a new concept called super-taxon to exploit hierarchical structure of taxa for micr

SUBMITTER: Dai W 

PROVIDER: S-EPMC9215102 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature