The Alteration of m⁶A Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester.

ABSTRACT: A growing number of studies have demonstrated that N6 methyladenine (m⁶A) acts as an important role in the pathogenesis of reproductive diseases. Therefore, it is essential to profile the genome-wide m⁶A modifications such as in spontaneous abortion. In this study, due to the trace of human villi during early pregnancy, we performed high-throughput sequencing in villous tissues from spontaneous abortion (SA group) and controls with induced abortion (normal group) in the first trimester. Based on meRIP-seq data, 18,568 m⁶A peaks were identified. These m⁶A peaks were mainly located in the coding region near the stop codon and were mainly characterized by AUGGAC and UGGACG motif. Compared with normal group, the SA group had 2,159 significantly upreg

SUBMITTER: She J 

PROVIDER: S-EPMC9215105 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature