A Possible Sterilizing Cure of HIV-1 Infection Without Stem Cell Transplantation.

ABSTRACT:

Background

A sterilizing cure of HIV-1 infection has been reported in 2 persons living with HIV-1 who underwent allogeneic hematopoietic stem cell transplantations from donors who were homozygous for the CCR5Δ32 gene polymorphism. However, this has been considered elusive during natural infection.

Objective

To evaluate persistent HIV-1 reservoir cells in an elite controller with undetectable HIV-1 viremia for more than 8 years in the absence of antiretroviral therapy.

Design

Detailed investigation of virologic and immunologic characteristics.

Setting

Tertiary care centers in Buenos Aires, Argentina, and Boston, Massachusetts.

Patient

A patient with HIV-1 infection and durable drug-free suppression of HIV-1 replication.

Measurements

Analysis of gen

SUBMITTER: Turk G 

PROVIDER: S-EPMC9215120 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature