Ontology highlight
ABSTRACT:
SUBMITTER: Silvian LF
PROVIDER: S-EPMC9215347 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Frontiers in aging neuroscience 20220608
There has been long-term interest in drugging the PINK1-Parkin pathway with therapeutics as a treatment for Parkinson's disease (PD). Despite significant structural data on Parkin as well as the PINK1 kinase and the multiple conformational changes it undergoes, activation of these targets is non-trivial. This review highlights small molecule screening results that suggests that activation of Parkin biochemically does not necessarily translate to activation of Parkin within cells. There are also ...[more]