Human plasma proteomic profiles indicative of cardiorespiratory fitness.
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ABSTRACT:
SUBMITTER: Robbins JM
PROVIDER: S-EPMC9216203 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Robbins Jeremy M JM Peterson Bennet B Schranner Daniela D Tahir Usman A UA Rienmüller Theresa T Deng Shuliang S Keyes Michelle J MJ Katz Daniel H DH Beltran Pierre M Jean PMJ Barber Jacob L JL Baumgartner Christian C Carr Steven A SA Ghosh Sujoy S Shen Changyu C Jennings Lori L LL Ross Robert R Sarzynski Mark A MA Bouchard Claude C Gerszten Robert E RE
Nature metabolism 20210527 6
Maximal oxygen uptake (VO<sub>2</sub>max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO<sub>2</sub>max, and of increases of VO<sub>2</sub>max in response to exercise training (ΔVO<sub>2</sub>max), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise ...[more]
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