Human plasma proteomic profiles indicative of cardiorespiratory fitness.

ABSTRACT: Maximal oxygen uptake (VO₂max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO₂max, and of increases of VO₂max in response to exercise training (ΔVO₂max), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise intervention and identify 147 proteins and 102 proteins whose plasma levels are associated with baseline VO₂max and ΔVO₂max, respectively. Addition of a protein biomarker score derived from these proteins to a score based on clinical traits improves the prediction of an individ

SUBMITTER: Robbins JM 

PROVIDER: S-EPMC9216203 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature