The moderating effect of cortisol and dehydroepiandrosterone on the relation between sleep and depression or burnout.

ABSTRACT: For poor sleep quality (SQ) as well as major depressive disorder (MDD) and burnout, a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been identified. Although poor SQ is often reported as an early symptom of MDD or burnout, it is not clear whether HPA axis-related hormones can influence the association between SQ and MDD or burnout. This manuscript addresses this question by examining HPA axis-related hormones as potential moderators influencing the association between SQ and MDD or burnout. In the fourth annual examination wave of the Dresden Burnout Study, we measured general SQ (including sleep duration and efficiency), depressive and burnout symptoms, and obtained hair samples for quantification of long-term integrated steroid concentrations (cortisol [hC], cortison

SUBMITTER: Rothe N 

PROVIDER: S-EPMC9216258 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature