Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes.

ABSTRACT:

Objective

Olanzapine and Aripiprazole are widely used second-generation antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic side effects including obesity and diabetes. While the underlying mechanisms are not fully understood, these side effects are likely associated with mild inflammation in the metabolic organs. An in vitro model that accurately recapitulates the metabolic impact of olanzapine and aripiprazole should be useful to elucidate the underlying mechanisms.

Methods

We established co-cultures of matured adipocytes derived from the human SGBS cell line and the THP-1 human monocytic cell-derived or primary macrophages to explore the effects of both drugs on the response to insulin.

Results

Olanzapine, but not aripipr

SUBMITTER: Dipta P 

PROVIDER: S-EPMC9216267 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature