Possible association of rotavirus IgG with cytokine expression levels and dyslipidemia in rotavirus-infected type 1 diabetic children.

ABSTRACT:

Background

Rotavirus (RV) has been postulated as a viral trigger for the onset of autoimmune disorders, such as type 1 diabetes (T1D). This study aimed to examine the conceivable association of RV IgG with cytokine levels and dyslipidemia in the pathogenesis of pediatric T1D.

Methods

This study included 30 healthy controls and 80 children with T1D who were divided into two groups based on the time since their T1D diagnosis: newly diagnosed (ND ≤ 1 year; n = 30) and previously diagnosed (PD > 1 year; n = 50). ND and PD patients were also separated into negative and positive according to IgG detection (RV IgG^-, ND^-, and PD^-; RV IgG⁺, ND⁺, and PD⁺).

Results

Positive polymerase chain reaction for RVs was ev

SUBMITTER: Khalil RG 

PROVIDER: S-EPMC9216291 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature