Intervention strategies for microbial therapeutics in cancer immunotherapy.

ABSTRACT: Immunotherapies have drastically improved clinical outcomes in a wide range of malignancies. Nevertheless, patient responses remain highly variable, and reliable biomarkers that predict responses accurately are not yet fully understood. Compelling evidence from preclinical studies and observational data from clinical cohorts have shown that commensal microorganisms that reside in the human gastrointestinal tract, collectively termed the 'microbiome', can actively modify responses to chemotherapeutic agents and immunotherapies by influencing host immunosurveillance. Notably, microbial correlates are largely context specific, and response signatures may vary by patient population, geographic location and type of anticancer treatment. Therefore, the incongruence of beneficial microbiome signa

SUBMITTER: Gopalakrishnan V 

PROVIDER: S-EPMC9216385 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature