LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response.

ABSTRACT: Growing evidence indicates that disturbances in the inflammatory response system can have deleterious effects on neuronal function and mental health. While the correlation between elevated peripheral inflammatory markers and psychiatric disorders are well documented, the exact molecular and neuronal mechanism underlying the connection between activated inflammation and neuropsychiatric behaviour remain elusive. Microglia activation is the key interface between neuro-inflammation and manifestation of psychiatric symptoms. Microglia are immunocompetent cells in the central nervous system (CNS) which are primarily involved in the response to inflammatory stimulation and are widely used to study neuroinflammation and test anti-inflammatory chemicals. In the brain, activated microglia play very

SUBMITTER: Lu Z 

PROVIDER: S-EPMC9216426 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature