DSDBASE 2.0: updated version of DiSulphide dataBASE, a database on disulphide bonds in proteins.

ABSTRACT: Disulphide bonds are stabilizing crosslinks in proteins and serve to enhance their thermal stability. In proteins that are small and rich in disulphide bonds, they could be the major determining factor for the choice of conformational state since their constraints on appropriate backbone conformation can be substantial. Such crosslinks and their positional conservation could itself enable protein family and functional association. Despite the importance of the field, there is no comprehensive database on disulphide crosslinks that is available to the public. Herein we provide information on disulphides in DSDBASE2.0, an updated and significantly expanded database that is freely available, fully annotated and manually curated database on native and modelled disulphides. The web interface al

SUBMITTER: Kalmankar NV 

PROVIDER: S-EPMC9216586 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature