Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019.

ABSTRACT:

Background

Progressive hypoxemia is the predominant mode of deterioration in COVID-19. Among hypoxemia measures, the ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen (P/F ratio) has optimal construct validity but poor availability because it requires arterial blood sampling. Pulse oximetry reports oxygenation continuously, but occult hypoxemia can occur in Black patients because the technique is affected by skin color. Oxygen dissociation curves allow non-invasive estimation of P/F ratios (ePFR) but this approach remains unproven.

Research question

Can ePFRs measure overt and occult hypoxemia?

Study design and methods

We retrospectively studied COVID-19 hospital encounters (n=5319) at two academic centers (University of Virginia [UVA

SUBMITTER: Gadrey SM 

PROVIDER: S-EPMC9216725 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature