Single Cell Meta-Analysis of Endothelial to Mesenchymal Transition (EndMT) in Glucose Metabolism of the Digestive Diseases.

ABSTRACT: Background: Endothelial-to-mesenchymal transition (EndMT) is poorly understood in digestive diseases, and the function of metabolism in EndMT is uncertain. Objective: The goal of this study is to elucidate the role of EndMT in digestive diseases and to describe its metabolic state. Method: The GEO database was used to extract single-cell data in order to discover EndMT subpopulations in digestive organs such as premalignant lesions and cancer of the stomach, intestine, and pancreas. Results: By single-cell RNA sequencing in digestive diseases, we generated a single-cell atlas from tissues of patients spanning a cascade of premalignant lesions and cancer. We next established a single-cell network elucidating the cellular and molecular characteristics of endotheli

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9216733 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature