Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn's disease.

ABSTRACT: Patients with inflammatory bowel disease (IBD) are particularly susceptible to behavioral diagnoses, and the microbiome has been repeatedly implicated in the pathogenesis of IBD. The intestinal microbiome's ability to affect behavior has become increasingly recognized and studied. The so-called 'psychobiome' has been linked to a plethora of neurological and psychological diagnoses, including autism and Parkinson's disease. Despite the ability of many bacterial species within the human intestinal microbiome to synthesize neurotransmitters, it has never been previously reported that a single bacterial species is sufficient to induce depression. Here, we demonstrate that our mouse model of Crohn's disease (CD)-like ileitis, the SAMP1/YitFc (SAMP1), does not exhibit baseline behavioral abnorma

SUBMITTER: Gomez-Nguyen A 

PROVIDER: S-EPMC9217177 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature