Identification of the Potential Correlation between Tumor Protein 73 and Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinomas (HNSC) are common malignant tumors with a high occurrence and poor prognosis. Tumor protein P73 (TP73) plays an integral role in a wide range of human malignancies, but its gene expression profile, prognostic value, and potential mechanisms in HNSC remain to be comprehensively explored.

Objective

This research aimed to elucidate the potential relationship between TP73 and HNSC through bioinformatics analysis.

Methods

The Cancer Genome Atlas (TCGA) database was queried to investigate the regulatory role of TP73 in HNSC. The survival probabilities linked to TP73 mRNA were determined via the Kaplan-Meier analysis using R packages. Subsequently, the association of TP73 with several clinical subgroups and immunological subt

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9217540 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature