Identification of biomarkers for immunotherapy response in prostate cancer and potential drugs to alleviate immunosuppression.

ABSTRACT:

Background

Immunotherapy has a significant effect on the treatment of many tumor types. However, prostate cancers generally fail to show significant responses to immunotherapy owing to their immunosuppressive microenvironments. To sustain progress towards more effective immunotherapy for prostate cancer, comprehensive analyses of the genetic characteristics of the immune microenvironment and novel therapeutic strategies are required.

Methods

The transcriptome profiles of patients with prostate cancer were obtained from GEO and processed with the TIDE algorithm to predict their responses to immunotherapy. Next, the significant differentially expressed genes (DEGs) between the responder and non-responder groups were identified and used to compute the co-expression modules by W

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9217695 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature