Diagnostic value of micrographia in Parkinson's disease: a study with [¹²³I]FP-CIT SPECT.

ABSTRACT: Micrographia is a common symptom of Parkinson's disease (PD), and it may precede other motor symptoms. Despite the high prevalence of micrographia in PD, its neurobiological mechanisms are not known. Given that levodopa may alleviate consistent micrographia and that nondopaminergic essential tremor (ET) is not associated with micrographia, micrographia could possibly be used as an ancillary diagnostic method that reflects nigrostriatal dopamine function. We evaluated the usefulness of micrographia as a simple one-sentence writing test in differentiating PD from ET. A total of 146 PD patients, 42 ET patients and 38 healthy controls provided writing samples and were scanned with brain [¹²³I]FP-CIT dopamine transporter (DAT) SPECT imaging with ROI-based and voxelwise analyses. The

SUBMITTER: Eklund M 

PROVIDER: S-EPMC9217822 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature