Risk of coronary stenosis after adjuvant radiotherapy for breast cancer.

ABSTRACT:

Purpose

Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer receiving adjuvant RT.

Methods

A cohort of women diagnosed with breast cancer between 1992 and 2012 in three Swedish health care regions (n = 57,066) were linked to the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) to identify women receiving RT who subsequently underwent a percutaneous coronary intervention (PCI) due to coronary stenosis. Cox regression analyses were performed to examine risk of a coronary intervention and competing risk analyses were performed to calculate cumulative incidence.

Results

A total of 649 women with left-sided bre

SUBMITTER: Wennstig AK 

PROVIDER: S-EPMC9217856 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature