Ontology highlight
ABSTRACT:
SUBMITTER: Banjarnahor S
PROVIDER: S-EPMC9217908 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Banjarnahor Sofna S König Jörg J Maas Renke R
Amino acids 20220404 7
The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of L-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of L-arginine, L-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effe ...[more]