A hierarchical vascularized engineered bone inspired by intramembranous ossification for mandibular regeneration.

ABSTRACT: Mandibular defects caused by injuries, tumors, and infections are common and can severely affect mandibular function and the patient's appearance. However, mandible reconstruction with a mandibular bionic structure remains challenging. Inspired by the process of intramembranous ossification in mandibular development, a hierarchical vascularized engineered bone consisting of angiogenesis and osteogenesis modules has been produced. Moreover, the hierarchical vascular network and bone structure generated by these hierarchical vascularized engineered bone modules match the particular anatomical structure of the mandible. The ultra-tough polyion complex has been used as the basic scaffold for hierarchical vascularized engineered bone for ensuring better reconstruction of mandible function. Acco

SUBMITTER: Ye X 

PROVIDER: S-EPMC9217949 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature