A Microbiota-Dependent Subset of Skin Macrophages Protects Against Cutaneous Bacterial Infection.

ABSTRACT: Microbiota is essential to the development and functional maturation of the immune system. The effects of the gut microbiota on myeloid cells remote from the gut, especially the skin remain unclear. Transcriptomic analysis revealed that type I interferon (IFN) signaling was down-regulated in the skin of germ-free mice compared to that in specific pathogen-free mice. The decrease in type I IFN signaling was closely related to the presence of microbiota and macrophage-specific marker CD169. The absence of CD169⁺ macrophages resulted in increased bacterial burden and impaired immune responses against Staphylococcus aureus skin infection. CD169⁺ macrophages mediated the recruitment of γδ T cells as well as the activation of γδ T cells via interleukin (IL)-23. Our findings

SUBMITTER: Park YJ 

PROVIDER: S-EPMC9218056 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature