The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis.

ABSTRACT: The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we created mice brain connectome and chemo-connectome databases based on mouse brain projection data of 295 non-overlapping brain areas and in situ hybridization (ISH) data of 50 representative neurotransmission-related genes from the Allen Brain Institute. Based on this connectome and chemo-connectome databases, functional connection patterns and detailed chemo-connectome for monoaminergic nuclei were analyzed and visualized. These databases will aid in the comprehensive research of the mouse con

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9218099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature