Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation.

ABSTRACT: Pain is an individual experience. Previous studies have highlighted changes in brain activation and morphology associated with within- and interindividual pain perception. In this study we sought to characterize brain mechanisms associated with between-individual differences in pain in a sample of healthy adolescent and adult participants (N = 101). Here we show that pain ratings varied widely across individuals and that individuals reported changes in pain evoked by small differences in stimulus intensity in a manner congruent with their pain sensitivity, further supporting the utility of subjective reporting as a measure of the true individual experience. Furthermore, brain activation related to interindividual differences in pain was not detected, despite clear sensitivity of the Blood

SUBMITTER: Hoeppli ME 

PROVIDER: S-EPMC9218124 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature