Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study.

ABSTRACT:

Background

Glycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury (TBI). We investigated longitudinal glycome patterns in patients with moderate to severe TBI (Glasgow Coma Scale [GCS] score ≤12) to characterize glyco-biomarker signatures and their relation to clinical features and long-term outcome.

Methods

This prospective single-center observational study included 51 adult patients with TBI (GCS ≤12) admitted to the neurosurgical unit of the University Hospital of Pecs, Pecs, Hungary, between June 2018 and April 2019. We used a high-throughput liquid chromatography-tandem mass spectrometry platform to assess serum leve

SUBMITTER: Mondello S 

PROVIDER: S-EPMC9218141 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature