Gut Microbiota Characteristics Are Associated With Severity of Acute Radiation-Induced Esophagitis.

ABSTRACT:

Background

Acute radiation-induced esophagitis (ARIE) is one of the most debilitating complications in patients who receive thoracic radiotherapy, especially those with esophageal cancer (EC). There is little known about the impact of the characteristics of gut microbiota on the initiation and severity of ARIE.

Materials and methods

Gut microbiota samples of EC patients undergoing radiotherapy (n = 7) or concurrent chemoradiotherapy (n = 42) were collected at the start, middle, and end of the radiotherapy regimen. Assessment of patient-reported ARIE was also performed. Based on 16S rRNA gene sequencing, changes of the gut microbial community during the treatment regimen and correlations of the gut microbiota characteristics with the severity of ARIE were invest

SUBMITTER: Lin MQ 

PROVIDER: S-EPMC9218355 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature