Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision.

ABSTRACT: To evaluate the nature of interactions between visual pathways transmitting the slower melanopsin and faster rod and cone signals, we implement a temporal phase summation paradigm in human observers using photoreceptor-directed stimuli. We show that melanopsin stimulation interacts with and alters both rod-mediated and cone-mediated vision regardless of whether it is perceptually visible or not. Melanopsin-rod interactions result in either inhibitory or facilitatory summation depending on the temporal frequency and photoreceptor pathway contrast sensitivity. Moreover, by isolating rod vision, we reveal a bipartite intensity response property of the rod pathway in photopic lighting that extends its operational range at lower frequencies to beyond its classic saturation limits but at the exp

SUBMITTER: Uprety S 

PROVIDER: S-EPMC9218364 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature