The spectrum of indomethacin-responsive headaches in children and adolescents.

ABSTRACT:

Background

Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied.

Methods

We reviewed pediatric patients with headache showing ≥80% improvement with indomethacin, from seven academic medical centers.

Results

We included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2-16 y). Headache syndromes included hemicrania continua (n = 13), paroxysmal hemicrania (n = 10), primary stabbing headache (n = 2), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n = 1), primary exercise headache (n = 1) and primary cough headache (n = 1). Adverse events were reported in 13, most commonly gastrointestinal symptoms,

SUBMITTER: Myers KA 

PROVIDER: S-EPMC9218410 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature