Prediction of the generalization of myasthenia gravis with purely ocular symptoms at onset: a multivariable model development and validation.

ABSTRACT:

Background

About half of myasthenia gravis (MG) patients with purely ocular symptoms at onset progress to generalized myasthenia gravis (gMG).

Objectives

To develop and validate a model to predict the generalization of MG at 6 months after disease onset in patients with ocular-onset myasthenia gravis (OoMG).

Methods

Data of patients with OoMG were retrospectively collected from two tertiary hospitals in Germany and China. An accelerated failure time model was developed using the backward elimination method based on the German cohort to predict the generalization of OoMG. The model was then externally validated in the Chinese cohort, and its performance was assessed using Harrell's C-index and calibration plots.

Results

Four hundred and seventy-seven patients (2

SUBMITTER: Li F 

PROVIDER: S-EPMC9218496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature