Tph Cells Expanded in Primary Sjogren's Syndrome.

ABSTRACT:

Objectives

PD-1⁺CXCR5^-CD4⁺T peripheral helper cells, named Tph cells, contribute to B-cell immune responses and the production of antibodies in systemic lupus erythematosus and rheumatoid arthritis. However, the role of Tph cells was unknown in the pathogenesis of primary Sjögren's syndrome (pSS). Here, we aim to explore the contribution of Tph cells in the development of pSS.

Methods

Sixty patients with pSS and 61 age and sex-matched healthy individuals were recruited for this study. The frequency of Tph cells in the blood was measured by flow cytometry. The expression of inducible T-cell costimulator (ICOS), MHC-II, IL-21, CCR2, CCR5, and CCR9 was evaluated in Tph cells. The relationship between Tph cells and indicators of clinical disease

SUBMITTER: Chen W 

PROVIDER: S-EPMC9218540 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature