Promoter Specific Methylation of SSTR4 is Associated With Alcohol Dependence in Han Chinese Males.

ABSTRACT: Alcohol dependence (AD), a disease can be affected by environmental factors with epigenetic modification like DNA methylation changes, is one of the most serious and complex public health problems in China and worldwide. Previous findings from our laboratory using the Illumina Infinium Human Methylation450 BeadChip suggested that methylation at the promoter of SSTR4 was one of the major form of DNA modification in alcohol-dependent populations. To investigate whether DNA methylation levels of the SSTR4 promoter influence alcohol-dependent behaviors, genomic DNA was extracted from the peripheral blood sample of 63 subjects with AD and 65 healthy controls, and pyrosequencing was used to verify the results of BeadChip array. Linear regression was used to analyze the correlation

SUBMITTER: Zhao R 

PROVIDER: S-EPMC9218598 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature