Characterization of Integrin Molecular Tension of Human Breast Cancer Cells on Anisotropic Nanopatterns.

ABSTRACT: Physical interactions between cells and micro/nanometer-sized architecture presented in an extracellular matrix (ECM) environment significantly influence cell adhesion and morphology, often facilitating the incidence of diseases, such as cancer invasion and metastasis. Sensing and responding to the topographical cues are deeply associated with a physical interplay between integrins, ligands, and mechanical force transmission, ultimately determining diverse cell behavior. Thus, how the tension applied to the integrin-ligand bonds controls cells' response to the topographical cues needs to be elucidated through quantitative analysis. Here, in this brief research report, we reported a novel platform, termed "topo-tension gauge tether (TGT)," to visualize single-molecule force applied to the i

SUBMITTER: Kim KA 

PROVIDER: S-EPMC9218603 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature