Surgery versus Radiofrequency Ablation for Small Hepatocellular Carcinoma: A Randomized Controlled Trial (SURF Trial).

ABSTRACT:

Introduction

It remains unclear which surgery or radiofrequency ablation (RFA) is the more effective treatment for small hepatocellular carcinoma (HCC). We aimed to compare survival between patients undergoing surgery (surgery group) and patients undergoing RFA (RFA group).

Methods

We conducted a randomized controlled trial involving 49 institutions in Japan. Patients with Child-Pugh scores ≤7, largest HCC diameter ≤3 cm, and ≤3 HCC nodules were considered eligible. The co-primary endpoints were recurrence-free survival (RFS) and overall survival (OS). The current study reports the final result of RFS, and the follow-up of OS is still ongoing.

Results

During 2009-2015, 308 patients were registered. After excluding ineligible patients, the surgery and RFA groups includ

SUBMITTER: Takayama T 

PROVIDER: S-EPMC9218617 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature