Circ_0006174 promotes the malignancy of colorectal cancer cell via the miR‑1205/CCBE1/Wnt pathway.

ABSTRACT: Circular RNAs (circRNAs) are novel RNA transcripts that participate in cancer development. Nonetheless, in colorectal cancer (CRC), the information ~circRNA expression and function is largely unknown. The present study aimed to investigate the expression, function and underlying mechanism of circ_0006174 in CRC. Reverse transcription‑quantitative PCR analysis was performed to detect circ_0006174, miR‑1205 and calcium‑binding epidermal growth factor domain‑containing protein 1 (CCBE1) expression levels in CRC tissues and cell lines. Circ_0006174 knockdown CRC cell models were established. CCK‑8, TUNEL and Transwell methods were utilized to explore the function of circ_0006174 on the malignant phenotype of CRC cells. Moreover, a xenograft nude mouse model was constructed to verify the effect

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9218732 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature