Upregulation of cadherin-11 contributes to cholestatic liver fibrosis.

ABSTRACT:

Importance

Cadherin-11 (CDH11), a cell-to-cell adhesion molecule, is implicated in the fibrotic process of several organs. Biliary atresia (BA) is a common cholestatic liver disease featuring cholestasis and progressive liver fibrosis in children. Cholestatic liver fibrosis may progress to liver cirrhosis and lacks effective therapeutic strategies. Currently, the role of CDH11 in cholestatic liver fibrosis remains unclear.

Objective

This study aimed to explore the functions of CDH11 in cholestatic liver fibrosis.

Methods

The expression of CDH11 in BA livers was evaluated by database analysis and immunostaining. Seven BA liver samples were used for immunostaining. The wild type (Wt) and CDH11 knockout (CDH11^-/- ) mice were subjected to b

SUBMITTER: Wu B 

PROVIDER: S-EPMC9218970 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature