Cerium Oxide Nanoparticles with Entrapped Gadolinium for High T ₁ Relaxivity and ROS-Scavenging Purposes.

ABSTRACT: Gadolinium chelates are employed worldwide today as clinical contrast agents for magnetic resonance imaging. Until now, the commonly used linear contrast agents based on the rare-earth element gadolinium have been considered safe and well-tolerated. Recently, concerns regarding this type of contrast agent have been reported, which is why there is an urgent need to develop the next generation of stable contrast agents with enhanced spin-lattice relaxation, as measured by improved T ₁ relaxivity at lower doses. Here, we show that by the integration of gadolinium ions in cerium oxide nanoparticles, a stable crystalline 5 nm sized nanoparticulate system with a homogeneous gadolinium ion distribution is obtained. These cerium oxide nanoparticles with entrapped gadolinium deliv

SUBMITTER: Eriksson P 

PROVIDER: S-EPMC9218977 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature