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Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression.

ABSTRACT: This study was conducted to further investigate bioactive molecules from Sophora tonkinensis that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a new naturally occurring compound, 6-hydroxy-vitexin-2″-O-rhamnoside (7), was identified along with 30 known compounds. The calculation of the gauge-including atomic orbital (GAIO) and electronic circular dichroism (ECD) proposed the absolute configuration of 17 as (2S,3R)-methyl-2-(4-hydroxybenzyl)tartrate by comparing the calculated ECD with experimental data. All isolates were tested for their inhibitory effects on PCSK9 mRNA expression. Of the tested compounds, (+)-isolariciresinol (12) inhibited PCSK9 expression via downregulation of HNF1α and SREBPs.

SUBMITTER: Pel P 

PROVIDER: S-EPMC9219048 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Chemical Constituents from the Roots and Rhizomes of <i>Sophora tonkinensis</i> and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression.

Pel Pisey P   Chae Hee-Sung HS   Nhoek Piseth P   Kim Young-Mi YM   An Chae-Yeong CY   Yoo Hunseung H   Kang Minseok M   Kim Hyun Woo HW   Choi Young Hee YH   Chin Young-Won YW  

ACS omega 20220608 24

This study was conducted to further investigate bioactive molecules from <i>Sophora tonkinensis</i> that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a new naturally occurring compound, 6-hydroxy-vitexin-2″-<i>O</i>-rhamnoside (<b>7</b>), was identified along with 30 known compounds. The calculation of the gauge-including atomic orbital (GAIO) and electronic circular dichroism (ECD)  ...[more]

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