Functional cRGD-Conjugated Polymer Prodrug for Targeted Drug Delivery to Liver Cancer Cells.

ABSTRACT: To overcome the limitation of conventional nanodrugs in tumor targeting efficiency, coupling targeting ligands to polymeric nanoparticles can enhance the specific binding of nanodrugs to tumors. Cyclo(Arg-Gly-Asp-d-Phe-Lys) (abbreviated as c(RGDfK)) peptide has been widely adopted due to its high affinity to the tumor marker α_vβ₃ integrin receptor. In this study, we develop a cRGD peptide-conjugated camptothecin (CPT) prodrug, which enables self-assembly of nanoparticles for precise targeting and enrichment in tumor tissue. We first synthesized a camptothecin derivative (CPT-ss-N₃) with a reduction-sensitive bond and simultaneously modified PEG to obtain cRGD-PEG-N₃. After ring-opening polymerization of the 2-(but-3-yn-1-yolxy)-2-oxo-1,3,2

SUBMITTER: Zhou R 

PROVIDER: S-EPMC9219052 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature