Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model.

ABSTRACT:

Background

Asthma is a major cause of morbidity and mortality in humans. The mechanisms of asthma are still not fully understood. Leukocyte-specific protein-1 (LSP-1) regulates neutrophil migration during acute lung inflammation. However, its role in asthma remains unknown.

Methods

An OVA-induced mouse asthma model in LSP1-deficient (Lsp1^-/-) and wild-type (WT) 129/SvJ mice were used to test the hypothesis that the absence of LSP1 would inhibit airway hyperresponsiveness and lung inflammation.

Results

Light and electron microscopic immunocytochemistry and Western blotting showed that, compared with normal healthy lungs, the levels of LSP1 were increased in lungs of OVA-asthmatic mice. Compared to Lsp1^-/- OVA mice, WT OVA mice had higher levels of

SUBMITTER: Le NPK 

PROVIDER: S-EPMC9219131 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature