Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes.

ABSTRACT:

Background

Previous genome-wide association studies (GWAS) have identified numerous risk genes for lacunar stroke, but it is challenging to decipher how they confer risk for the disease. We employed an integrative analytical pipeline to efficiently transform genetic associations to identify novel proteins for lacunar stroke.

Methods

We systematically integrated lacunar stroke genome-wide association study (GWAS) (N=7338) with human brain proteomes (N=376) to perform proteome-wide association studies (PWAS), Mendelian randomization (MR), and Bayesian colocalization. We also used an independent human brain proteomic dataset (N=152) to annotate the new genes.

Results

We found that the protein abundance of seven genes (ICA1L, CAND2, ALDH2, MADD, MRVI1, CSPG4, and PTPN11)

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9219149 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature