Cobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions.

ABSTRACT:

Background

Complete healing of diabetic wounds continues to be a clinically unmet need. Although robust therapies such as stem cell therapy and growth factor treatment are clinically applied, these treatments are costly for most diabetic wound patients. Therefore, a cheaper alternative is needed. Cobalt protoporphyrin (CoPP) has recently been demonstrated to promote tissue regeneration. In this study, the therapeutic benefits of CoPP in diabetic wound healing were examined.

Methods

An in vitro wound healing model that mimics re-epithelialization was established to examine the effect of CoPP on the migratory capability of human keratinocytes (HaCaT) in either normal glucose (NG) or high glucose (HG) media, as well as in the presence of either H₂O₂ or lip

SUBMITTER: Fang PH 

PROVIDER: S-EPMC9219158 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature