Ontology highlight
ABSTRACT:
SUBMITTER: Guenther M
PROVIDER: S-EPMC9219162 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Guenther Michael M Gil Lina L Surendran Sai Agash SA Palm Melanie Alexandra MA Heinemann Volker V von Bergwelt-Baildon Michael M Mayerle Julia J Engel Jutta J Werner Jens J Boeck Stefan S Ormanns Steffen S
JNCI cancer spectrum 20220501 3
Adjuvant gemcitabine (aGC) is one standard of care after pancreatic ductal adenocarcinoma (PDAC) resection. No biomarker for its efficacy is established. As bacteria mediate gemcitabine resistance, we analyzed whether lipopolysaccharide (LPS) as surrogate for bacterial colonization is prognostic in PDAC patients treated with aGC or without aGC adjuvant gemcitabine. We detected LPS in 86 tumors from 376 patients, which defined a specific microbiome as revealed by 16 s-rRNA-sequencing. In the 230 ...[more]