Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population.

ABSTRACT:

Background

PCSK9 gene expression is associated with biological processes such as lipid metabolism, glucose metabolism, and inflammation. In the present study, our primary objective was to assess the association between the single-nucleotide polymorphisms in the PCSK9 gene and type 2 diabetes in Uygur subjects, in Xinjiang, China.

Methods

We designed a case-control study including 662 patients diagnosed with T2DM and 1220 control subjects. Four single-nucleotide polymorphisms (rs11583680, rs2483205, rs2495477 and rs562556) of PCSK9 gene were genotyped using the improved multiplex ligation detection reaction technique.

Results

For rs2483205, the distribution of genotypes, dominant model (CC vs CT + TT), overdominant model (CC + TT vs CT) showed significant differences b

SUBMITTER: Wang MM 

PROVIDER: S-EPMC9219175 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature