Application of circulating tumour cells to predict response to treatment in head and neck cancer.

ABSTRACT:

Background

Local recurrence and metastasis remain the major causes of death in head and neck cancer (HNC) patients. Circulating tumour cells (CTCs) are shed from primary and metastatic sites into the circulation system and have been reported to play critical roles in the metastasis and recurrence of HNC. Here, we explored the use of CTCs to predict the response to treatment and disease progression in HNC patients.

Methods

Blood samples were collected at diagnosis from HNC patients (n = 119). CTCs were isolated using a spiral microfluidic device and were identified using immunofluorescence staining. Correlation of baseline CTC numbers to 13-week PET-CT data and multidisciplinary team consensus data were conducted.

Results

CTCs were detected in 60/119 (50.4%) of treatme

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9219366 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature