Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change.

ABSTRACT: Endocrine regulation in the hypothalamic-pituitary-thyroid (HPT) axis is orchestrated by physiological circuits which integrate multiple internal and external influences. Essentially, it provides either of the two responses to overt biological challenges: to defend the homeostatic range of a target hormone or adapt it to changing environmental conditions. Under certain conditions, such flexibility may exceed the capability of a simple feedback control loop, rather requiring more intricate networks of communication between the system's components. A new minimal mathematical model, in the form of a parametrized nonlinear dynamical system, is here formulated as a proof-of-concept to elucidate the principles of the HPT axis regulation. In particular, it allows uncovering mechanisms for the hom

SUBMITTER: Hoermann R 

PROVIDER: S-EPMC9219553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature