<i>De Novo</i> Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery.

ABSTRACT:

Background

Glycine is a dietary non-essential amino acid that is low in obesity and increases following bariatric surgery. However, the exact mechanism responsible remains unclear and it is unknown whether hypoglycinemia is a cause or consequence of insulin resistance.

Objective

Using multiple isotopically labeled tracers, we aimed to determine the underlying kinetic changes responsible for hypoglycinemia in obesity by: 1) Comparing glycine kinetics between participants with morbid obesity (BMI ≥ 32.5 kg/m²) to those with healthy weight (BMI < 25 kg/m²), and 2) Comparing glycine kinetic changes in participants with morbid obesity after bariatric surgery.

Methods

[1,2-¹³C₂] glycine, [2,3,3-²H₃] serine, a

SUBMITTER: Tan HC 

PROVIDER: S-EPMC9219591 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature