Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association.

ABSTRACT: Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products. Aggregation can cause immunogenicity, viscosity and stability issues affecting both the safety and quality of the product. As the hydrophobic residues on the CDR are required for direct binding to antigens, it is not always possible to substitute these residues for aggregation-reduction purposes. Therefore, discovery of specific excipients to prevent aggregation is highly desirable for formulation development. Here, we used a combination of in silico screening methods to identify aggregation-prone regions on an aggregation-prone therapeutic antib

SUBMITTER: Lui LH 

PROVIDER: S-EPMC9219649 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature