Prognostic Implications of Portal Venous Circulating Tumor Cells in Resectable Pancreatic Cancer.

ABSTRACT: Circulating tumor cells (CTCs) are a promising prognostic biomarker for cancers. However, the paucity of CTCs in peripheral blood in early-stage cancer is a major challenge. Our study aimed to investigate whether portal venous CTCs can be a biomarker for early recurrence and poor prognosis in pancreatic cancer. Patients who underwent upfront curative surgery for resectable pancreatic cancer were consecutively enrolled in this prospective study. Intraoperatively, 7.5 mL of portal and peripheral blood was collected, and CTC detection and identification were performed using immunofluorescence staining. Peripheral blood CTC sampling was performed in 33 patients, of which portal vein CTC sampling was performed in 28. The median portal venous CTCs (2.5, interquartile ranges (IQR) 1-7.75) were si

SUBMITTER: Choi YH 

PROVIDER: S-EPMC9219704 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature