Systemic Inflammation Predicts Alzheimer Pathology in Community Samples without Dementia.

ABSTRACT: Neuroinflammation and oxidative stress (OS) are implicated in the pathophysiology of Alzheimer's disease (AD). However, it is unclear at what stage of the disease process inflammation first becomes manifest. The aim of this study was to investigate the associations between specific plasma markers of inflammation and OS, tau, and Amyloid-β 38, 40, and 42 levels in cognitively unimpaired middle-age and older individuals. Associations between inflammatory states identified through principal component analysis and AD biomarkers were investigated in middle-age (52-56 years, n = 335, 52% female) and older-age (72-76 years, n = 351, 46% female) participants without dementia. In middle-age, a component reflecting variation in OS was most strongly associated with tau and to a lesser e

SUBMITTER: Cherbuin N 

PROVIDER: S-EPMC9219863 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature