Reprogrammed CD8⁺ T-Lymphocytes Isolated from Bone Marrow Have Anticancer Potential in Lung Cancer.

ABSTRACT: CD8⁺ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy. In this study, reprogrammed T-lymphocytes used MEK inhibitors and PD-1 blockers to increase their antitumor activity. Antitumor effects of reprogrammed T-lymphocytes were shown in vitro and in vivo in the Lewis lung carcinoma model. The population of T- lymphocytes with persistent expression of CCR7 was formed as a result of reprogramming. Reprogrammed T-lymphocytes were resistant to apoptosis and characterized by high cytotoxicity against Lewis lung carcinoma (LLC) cells in vitro. Administration of reprogrammed T-lymphocytes to C57BL/6 mic

SUBMITTER: Skurikhin EG 

PROVIDER: S-EPMC9219954 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature