Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures.

ABSTRACT:

Background

Exposure to traumatic events is a risk factor for negative physical and mental health outcomes. However, the underlying biological mechanisms that perpetuate these lasting effects are not known.

Methods

We investigated the impact and timing of sexual trauma, a specific type of interpersonal violence, experienced during key developmental windows of childhood, adolescence, or adulthood on adult health outcomes and associated biomarkers, including circulating cell-free mitochondrial DNA levels and extracellular vesicles (EVs), in a predominantly Black cohort of women (N = 101).

Results

Significant changes in both biomarkers examined, circulating cell-free mitochondrial DNA levels and EV proteome, were specific to developmental timing of sexual trauma. Specific

SUBMITTER: Morrison KE 

PROVIDER: S-EPMC9219961 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature